Temporal and spatial multiscale challenges appear because the material response of crystalline solids is characterized by the nucleation and dynamics of defects such as point defects (vacancies, interstitials, impurities), line defects (dislocations), and surface defects (grain boundaries, surfaces, cracks, etc.). To overcome these challenges and reach mesoscopic scales, we have developed the Hyper-QC method to coarse-grain space by the finite temperature quasicontinuum method and accelerate time by the hyperdynamics method.