Computational studies of blood flow often seek to understand how local flow mechanics relate to disease progression. Of particular interest are biomechanical interactions between blood flow and the vessel wall, which is a nexus for pathology. In the near-wall region, blood flow imparts mechanical stresses on the vessel wall, and regulates the local transport of reactive material between the tissue and fluid domains. The latter mechanism, transport, is difficult to quantify since it is an emergent and chaotic process. Moreover, in arterial flows, there is disparate spatial and temporal scales between the macro fluid mechanics and near-wall processes. This talk will discuss our recent work to better characterize and tractably model near-wall transport in large-artery flows.