Several phenomena in the physical and the life sciences can be modeled as a time dependent interface problem and nonlinear partial differential equations. Examples include the study of electro-osmotic flows, molecular beam Epitaxy, free surface flows and multiphase flows in porous media. One of the main difficulties in solving numerically these equations stems from the fact that the geometry of the problems is often arbitrary and special care is needed to correctly apply boundary conditions. Another difficulty is associated with the fact that such problems involve dissimilar length scales, with smaller scales influencing larger ones so that nontrivial pattern formation dynamics can be expected to occur at all intermediate scales. Uniform grids are limited in their ability to resolve small scales and are in such situations extremely inefficient in terms of memory storage and CPU requirements. In this talk, I will present recent advances in the numerical treatment of interface problems and describe new numerical solvers for nonlinear partial differential equations in the context of adaptive mesh refinement based on Octree grids. I will also present recent work on using machine learning in the context of interfaces problems.